Robles Lab

We study circadian- and sleep-driven mechanisms in health and diseases across molecular to system levels, using a variety of biochemical and cell biology approaches, with mass spectrometry (MS)-based quantitative proteomics as our core technology. We employ a wide range of proteomics approaches to investigate, in a context-dependent manner, the temporal dynamics of protein abundance, subcellular localization and post-transcriptional modifications (PTMs) that underpin circadian and sleep molecular processes.
To support our work, we continuously develop and optimize novel proteomics methods using our state-of-the-art instrumentation (funded by the DFG and LMU), including the Orbitrap Exploris™ 480 and Q-Exactive™ HF-X mass spectrometers and Vanquish Neo and EASY-nLC 1200 HPLCs. This instrumentation platform is located at the BMC, where our group is affiliated.