Circadian clocks are cell endogenous, self-sustainable oscillators present in virtually every cell in the body, playing a fundamental role in cellular and tissue physiology. This internal timing system enables our organs to molecularly anticipate and prepare their metabolism for daily recurrent needs associated with environmental changes. While the circadian clock regulates metabolism, metabolic states, in turn, provide feedback to the circadian clock, modulating its function. We are investigating this molecular crosstalk in peripheral metabolic tissues from mice, employing interaction and spatial proteomics as well as phosphoproteomics.
Part of this work is supported by the DFG within the CRC1064 Chromatin Dynamics
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