Robles Lab Publications

ElGrawani, W, Sun, G, Kliem, FP, Sennhauser, S, Pierre-Ferrer, S, Rosi-Andersen, A, Boccalaro, I, Bethge, P, Heo, WD, Helmchen, F, Adamantidis, AR*, Forger, DB*, Robles, MS* and Brown, SA* (2024). BDNF-TrkB signaling orchestrates the buildup process of local sleep. Cell reports, 43(7), 114500. doi.org/10.1016/j.celrep.2024.114500 * Equal contribution Pubmed

Carnie, CJ, Acampora, AC, Bader, AS, … Robles MS, … Jackson, SP and Stingele J. (2024). Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB. Nat Cell Biol. doi.org/10.1038/s41556-024-01391-1 Pubmed

Schmal C, Maier B, Ashwal-Fluss R, Bartok O, Finger AM, Bange T, Koutsouli S, Robles MS, Kadener S, Herzel H, Kramer A. (2023) Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock. PLoS Biol. Jun 28;21(6):e3002164. doi: 10.1371/journal.pbio.3002164. Pubmed

Paul MC, Schneeweis C, Falcomatà C, ... Robles MS, ..., Andrieux G, Boerries M, Rad R, Schneider G and Saur D. (2023) Non-canonical functions of SNAIL drive context-specific cancer progression. Nat Commun. doi.org/10.1038/s41467-023-36505-0 Pubmed

Kliem FP, Brüning F, Robles MS (2022) Proteomics Approaches to Assess Sleep and Circadian Rhythms. Circadian Clocks. Neuromethods doi.org/10.1007/978-1-0716-2577- 4_15

Hamzeiy H, Ferretti D, Robles MS*, and Cox J*. (2022) Perseus plugin ‘Metis’ for metabolic pathway-centered quantitative multi-omics data analysis supporting static and time-series experimental designs. Cell Reports Methods. doi.org/10.1016/j.crmeth.2022.100198. *co- corresponding author.. Pubmed

Schneeweis C, Hassan Z, Ascherl K, Wirth M, Koutsouli S, Orben F, Krauß L, Schneider C, Öllinger R, Krämer OH, Rad R, Reichert M, Robles MS, Saur D and Schneider G. (2022) Indirect targeting of MYC sensitizes pancreatic cancer cells to mechanistic target of rapamycin (mTOR) inhibition. Cancer Commun. doi:10.1002/cac2.12280 Pubmed

Falcomatà, C, Bärthel, S, Widholz, SA, ...Robles MS, ..., Schneider G and Saur D. (2022) Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment. Nat Cancer. doi: 10.1038/s43018-021-00326-1

Falcomatà C, Bärthel S, Ulrich A, S Diersch, ...Robles MS, ..., Schneider G and Saur D. (2021) Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer. (2021) Cancer Discov. doi: 10.1158/2159-8290.CD-21-0209PubMed

Hansen FM, Tanzer MC, Brüning F, Bludau I, Stafford C, Schulman BA, Robles MS*, Karayel O*, Mann M*. (2021) Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology. Nat Commun. doi: 10.1038/s41467-020- 20509-1.*co-corresponding authorPubMed

Brüning F, Humphrey SJ, Robles MS (2020) Phosphoproteome and Proteome Sample Preparation from Mouse Tissues for Circadian Analysis. Methods Mol Biol. doi: 10.1007/978-1-0716-0381-9_14. PubMed

Brüning F, Noya SB, Bange T, Koutsouli S, Rudolph JD, Tyagarajan SK, Cox J, Mann M, Brown SA*, Robles MS*. (2019) Sleep-wake cycles drive daily dynamics of synaptic phosphorylation. Science. doi: 10.1126/science.aav3617 *co-corresponding author PubMed

Noya SB, Colameo D, Brüning F, Spinnler A, Mircsof D, Opitz L, Mann M, Tyagarajan SK*, Robles MS*, Brown SA*. (2019) The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep. Science. doi: 10.1126/science.aav2642 *co- corresponding authorPubMed.

Harpprecht L, Baldi, S, Schauer T, Schmidt A, Bange T, Robles MS, Kremmer E, Imhof A and Becker PB. (2019) A Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling. Nucleic Acids Res. doi: 10.1093/nar/gkz473. PubMed

Korge S, Maier, B, Brüning, F, Ehrhardt, L, Korte, T, Mann, M, Herrmann, A, Robles MS and Kramer A. (2018) The non-classical nuclear import carrier Transportin 1 modulates circadian rhythms through its effect on PER1 nuclear localization. PLoS Genet. doi: 10.1371/journal.pgen.1007189.. PubMed

Hughes ME,..., Robles MS,..., Hogenesch JB. (2017) Guidelines for genome-scale analysis of biological rhythms. J Biol Rhythms doi: 10.1177/0748730417728663. PubMed Robles MS, Humphrey SJ and Mann M. (2017) Central role of phosphorylation in the circadian control of liver metabolism. Cell Metab doi: 10.1016/j.cmet.2016.10.004.

Robles MS, Humphrey SJ and Mann M. (2017) Central role of phosphorylation in the circadian control of liver metabolism. Cell Metab doi: 10.1016/j.cmet.2016.10.004. PubMed

Neufeld-Cohen A*, Robles MS*, Adamovich Y, Nir D, Rousso-Noori L, Yael Kuperman Y, Golik M, Mann M and Asher G#. (2016) Circadian control of mitochondrial nutrient utilization through regulation of rate-limiting mitochondrial enzymes. Proc Natl Acad Sci USA doi: 10.1073/pnas.1519650113 *Equal contribution; # corresponding author PubMed

Tamayo AG, Duong HA, Robles MS, Mann M, Weitz CJ. (2015) Histone mono- ubiquitination by a Clock–Bmal1 complex marks circadian clock genes for feedback repression. Nat Struct Mol Biol doi: 10.1038/nsmb.3076. PubMed

Robles MS, Cox J, Mann M. (2014) In-vivo quantitative proteomics reveals a key contribution of post-transcriptional mechanisms to the circadian regulation of liver metabolism. PLoS Genet. doi: 10.1371/journal.pgen.1004047. PubMed

Robles MS, Mann M. (2013) Proteomic approaches in circadian biology. Handb Exp Pharmacol. doi: 10.1007/978-3-642-25950-0_17 PubMed

Padmanabhan K, Robles MS, Westerling T, Weitz CJ. (2012) Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. doi: 10.1126/science.1221592. PubMed

Duong HA*, Robles MS*, Knutti D, Weitz CJ. (2011) A molecular mechanism for circadian clock negative feedback. Science. Jun 17; 332 (6036): 1436-9. *Equal contribution. PubMed

Robles MS*, Boyault C*, Knutti D*, Padmanabhan K, Weitz CJ. (2010) Identification of RACK1 and protein kinase C alpha as integral components of the mammalian circadian clock. Science. Jan 22; 327 (5964): 463-6. *Equal contribution PubMed

Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction. Pfaller CK, Conzelmann KK.
J Virol. 2008 Dec;82(24):12365-73. doi: 10.1128/JVI.01321-08. Epub 2008 Oct 15. PubMed

The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.
Cui S, Eisenächer K, Kirchhofer A, Brzòzka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A, Hopfner KP.
Mol Cell. 2008 Feb 1;29(2):169-79. doi: 10.1016/j.molcel.2007.10.032. PubMed

Double-labeled rabies virus: live tracking of enveloped virus transport.
Klingen Y, Conzelmann KK, Finke S.
J Virol. 2008 Jan;82(1):237-45. Epub 2007 Oct 10. PubMed

Robles MS, Leonardo EM, Izquierdo M and Martínez-A C. (2003) Exacerbated inflammatory responses in transgenic mice expressing an inhibitor of apoptosis protein (OpIAP). Cell Death and Differ. 10 (11): 1226-33. PubMed

Moreno de Alboran I, Robles MS, Bras A, Baena E and Martinez-AC. (2003) Cell death during lymphocyte development and activation. Seminars in Immunology, (15) 4: 121-199. PubMed

del Prete MJ, Robles MS, Guio A, Martinez-AC, Izquierdo M, and Garcia-Sanz JA. (2002) Degradation of cellular mRNA is a general early apoptosis-induced event. FASEB J, 14: 2003-5. PubMed

Robles MS, Leonardo E, Criado LM, Izquierdo M. and Martínez-AC. (2002) OpIAP provides a costimulatory signal required for optimal proliferation of developing thymocytes. Journal of Immunology, 168: 1770-1779. PubMed

Izquierdo M, Grandien A, Criado LM, Robles S, Leonardo E, Albar JP, de Buitrago GG and Martinez-AC. (1999) Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor. EMBO J, 18: 156-166. PubMed

Revilla V, Robles MS, Bermejo JC, Paniagua MA, Fernandez-Lopez A. (1999) Seizure-refractory period after a single stimulation and inhibition of seizures after repetitive stimulation in the gerbil: effects on blood cortisol levels. Epilepsia, 40(1): 1-4. PubMed