In mammals, circadian asynchrony leads to pathological conditions such as obesity and cancer. And, though it is still largely unclear how circadian clocks are linked to cancer development, the prevalent hypothesis is that the circadian clock promotes cellular fitness and thus works as a tumor suppressor. In collaboration with Dieter Saur (TUM, Munich) we are studying the interplay between circadian clocks and cancer, in pancreatic ductal adenocarcinoma (PDAC), the most frequent type of pancreatic cancer in humans and the fourth-leading cause of cancer-related deaths in western countries. By employing a multi-interdisciplinary approach, with quantitative proteomics as core, we are molecularly studying circadian function in PDAC.
Paul MC, Schneeweis C, Falcomatà C, ... Robles MS, ..., Andrieux G, Boerries M, Rad R, Schneider G and Saur D. (2023) Non-canonical functions of SNAIL drive context-specific cancer progression. Nat Commun. doi.org/10.1038/s41467-023-36505-0
Schneeweis C, Hassan Z, Ascherl K, Wirth M, Koutsouli S, Orben F, Krauß L, Schneider C, Öllinger R, Krämer OH, Rad R, Reichert M, Robles MS, Saur D and Schneider G. (2022) Indirect targeting of MYC sensitizes pancreatic cancer cells to mechanistic target of rapamycin (mTOR) inhibition. Cancer Commun. doi:10.1002/cac2.12280
Falcomatà, C, Bärthel, S, Widholz, SA, ...Robles MS, ..., Schneider G and Saur D. (2022) Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment. Nat Cancer. doi: 10.1038/s43018-021-00326-1
Falcomatà C, Bärthel S, Ulrich A, S Diersch, ...Robles MS, ..., Schneider G and Saur D. (2021) Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer. (2021) Cancer Discov. doi: 10.1158/2159-8290.CD-21-0209.