Steiner Lab
Biochemistry of γ-Secretase
© J. Greune / LMU
Prof. Dr. Harald Steiner
Biochemistry of γ-Secretase
Division of Biochemistry
+49 89 4400 46535
harald.steiner@med.uni-muenchen.de
Research Topics
- Recognition and processing of γ-secretase substrates
- Modulation of γ-secretase actvity
- Lipid dependence of γ-secretase activity
Our lab studies the function and mechanism of γ-secretase, a pivotal intramembrane protease complex critically involved in the generation of neurotoxic Alzheimer´s disease-associated amyloid-β peptides (Aβ), nuclear signaling and membrane proteostasis. We use state of the art biochemical, molecular biology and cell biological methods to get insight into how this fascinating proteolytic enzyme works. Read more...
Publications
Scientific vita
- since 2007
- Professor, Dept. Metabolic Biochemistry, Biomedical Center, LMU Munich
- 1999-2007
- Senior scientist and Group leader, Adolf-Butenandt-Institute, LMU Munich
- 1996-1999
- Postdoctoral researcher, Christian Haass Lab, Central Institute of Mental Health, Mannheim (University of Heidelberg)
- 1996
- PhD in Biochemistry, LMU Munich, Advisor: Walter Neupert