Siegel Lab
Molecular Parasitology
© J. Greune / LMU
Prof. Dr. Nicolai Siegel
Molecular Parasitology
Divisions of Physiological Chemistry and Experimental Parasitology
+49 89 2180 77098
n.siegel@lmu.de
Research Topics
- Chromatin organization
- Genome architecture
- Antigenic variation
- Trypanosoma brucei
We are interested in how pathogens benefit from cell-to-cell heterogeneity and in the mechanisms controlling heterogeneity in a population. Our research relies on different single cell technologies and many high throughput sequencing-based approaches to study the transcriptome, chromatin organization and genome architecture in unicellular eukaryotes. One key question of our research is how pathogens regulate antigenic variation at the genomic and transcriptional level. As a model we use the protozoan parasite Trypanosoma brucei, the causative agent of African sleeping sickness. Read more...
Publications
Scientific vita
- since 2017
- Professor, Faculty of Veterinary Medicine, Experimental Parasitology
Dept. Physiol. Chemistry, Biomedical Center Munich, LMU Munich - 2012-2017
- ZINF Young Investigator, Institute for Molecular Infection Biology, University of Würzburg
- 2010-2011
- EMBO / HFSP Postdoctoral Fellow, Scherf Lab, France Dept. of Parasitology & Mycology, Institut Pasteur, Paris, France
- 2009
- PhD, The Rockefeller University, New York, USA, Advisor: George Cross