Division of Physiological Chemistry
We investigate the nuclear and cellular processes of gene regulation and epigenetics that enable organisms to adapt physiologically to changing environmental conditions.
We are interested in dynamic processes at the cellular, genetic and epigenetic level. We study how certain metabolites regulate the activity of genes and influence central metabolic pathways. In addition, we analyze how stress situations (e.g. DNA damage) affect chromatin structure and the associated signaling networks. We also investigate the relationship between metabolites and neurodevelopmental disorders and develop computational models to identify which areas of the epigenome change under different conditions and how these changes affect the observed phenotype.
For our studies, we use powerful model organisms such as the fruit fly Drosophila melanogaster, the parasite Trypanosoma brucei, various yeast species, cultured mammalian cell lines and animal models. We are increasingly integrating our experimental methods with applied bioinformatics, especially in the context of single cell biology.
We apply methods with atomic resolution (structural biology, biophysics, biochemistry), use modern techniques of cell biology (e.g. "live-cell" imaging) and functional genomics. Our diversity of methods allows us to identify and validate new mechanisms from the atomic level to (patho)physiology in the organism. Our insights into these genetic, epigenetic and physiological mechanisms enable innovative translational activities, including the personal support of entrepreneurial career development and biotechnological spin-offs.
More information on the Physiological Chemistry website.
Research Groups
Division Head
© J. Greune / LMU
Prof. Dr. Andreas Ladurner
Biomedical Center
Großhaderner Straße 9
82152 Planegg-Martinsried