Burbulla Lab
Translational Disease Modeling
Translational Disease Modeling
© Jan Greune / LMU
Translational Disease Modeling
Division of Biochemistry
+49 89 4400 46493
lena.burbulla@med.uni-muenchen.de
Research Topics
The Burbulla lab aims to investigate underlying mechanisms of dopaminergic neuron degeneration in Parkinson’s disease and related disorders. We are interested in understanding the complexity of dopamine metabolism in pathology, specifically interactions between dopamine, iron and (mitochondrial) oxidant stress. Our work combines a portfolio of diverse techniques including iPSC culture, subsequent differentiation into disease-relevant cell types (midbrain dopaminergic neurons, astrocytes, microglia), biochemical and cellular assays, integrated multi-omics analyses, and HPLC-ECD. Our ultimate goal is to unravel novel targets for therapeutic intervention. Read more...