Division of Cell Biology - Anatomy III
At the interdisciplinary Division of Cell Biology, we investigate the cellular plasticity of adult tissues from primary neurons to cells of the reproductive system.
One of the main focuses of our division is exploring the cellular and molecular plasticity of neurons, particularly the changes occurring at individual synapses during learning (Kiebler lab). Synapses undergo dynamic alterations throughout an individual's life, playing a crucial role in learning and memory formation. A key aspect of this process is the localization of specific RNA molecules to the postsynaptic side of synapses, followed by activity-dependent local protein synthesis, which is regulated by RNA-binding proteins (RBPs). These mechanisms contribute significantly to synaptic plasticity.
In a parallel approach, we are investigating how newly formed neurons in adulthood ("adult neurogenesis") are integrated into the network of the Hippocampus and how age-related diseases influence the function of the hippocampal network (Pilz lab). The aim of these studies is to better understand the mechanisms of neuronal adaptation and degeneration.
The Ninkovic lab is developing strategies for the repair and regeneration of the brain. In particular, we are investigating how the glial cells can be functionally modified to promote the regeneration of neurons.
In addition to neurons, we also investigate fundamental mechanisms of human reproduction and its disorders. We use ovarian and testicular cells as model systems of the gonads in order to understand the differentiation and function of these cells and corresponding tumor cells (Mayerhofer lab).
We use state-of-the-art experimental cell biological approaches, from the culture of primary neurons including live cell imaging, spheroids and organoids to mouse models including genetics and molecular methods (hiCLIP, Mass Spec, proximity ligation assays) to comprehensively investigate complex cellular processes.
More information on the Cell Biology website.
Research groups
Division Head
© LMU
Prof. Dr. Michael Kiebler
Biomedical Center
Großhaderner Strasse 9
82152 Planegg-Martinsried