Russo Lab

Vergrößern

Dr. Marta Russo

Gene regulation and nuclear metabolism
Division of Physiological Chemistry

- This new lab group starts in summer 2025 -

Marta.Russo@ieo.it

Research Topics

• Functional dynamics and interactions of nuclear acyl-CoA producing enzymes with transcriptional machinery
• Impact of metabolic enzymes on chromatin modifications & gene activity
• Structure and biochemistry of nuclear acyl-CoA producing enzymes
  

Our lab investigates how nuclear metabolism shapes gene regulation and chromatin dynamics, with a particular focus on metabolic enzymes traditionally associated with mitochondria that have been recently discovered to also operate in the nucleus. We aim to uncover how these enzymes locally contribute to chromatin remodeling, histone modifications, and transcriptional regulation, influencing gene expression programs in response to metabolic and environmental signals. Using a combination of genomics, proteomics, metabolomics, imaging and biochemical approaches, we seek to define the molecular mechanisms driving gene expression plasticity across different cellular states and conditions. Read more...

Publications

https://orcid.org/0000-0003-1418-4712