Gerdes Lab

Vergrößern

PD Dr. Lisa Ann Gerdes

MS Twin Study
Institute of Clinical Neuroimmunology

+49 89 4400 74781/7478
lgerdes@med.lmu.de

Research Topics

• MS TWIN STUDY-clinical cohort of monozygotic twins with discordance for Multiple Sclerosis
• Identification of risk and trigger factors of MS. Immune pathogenesis of early MS
• Single cell sequencing in CSF and blood
• Gut microbial profiling and microbial transfer experiments into germ-free mice

Vergrößern

We have established a unique MS TWIN STUDY and are longitudinally following >100 pairs of monozygotic twins with discordance for Multiple Sclerosis. The aim of this study is to identify risk and trigger factors that differ between cases and controls matched not only for age, gender and genetic background, but also for a broad range of (early) environmental factors. In this high risk cohort we additionally explore early alterations in the immune system during prodromal MS leading to clinical MS manifestation. We use a wide range of methods from clinical phenotyping including innovative MRI imaging, optic coherence tomography and neuropsychological testing as well as a broad spectum of innovative research technologies such as single cell sequencing in CSF, deep microbial profiling and microbiome transfer experiments in a germ-free spontaneous EAE model as well as epigenetics (including scATAC) and genetics. Read more...

Publications

https://orcid.org/0000-0002-7053-3924

Scientific vita