Margulies Lab
The regulation of metabolism and appetite
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We are exploring the role of chromatin in regulating metabolism and appetite control. Using Drosophila melanogaster as model system we are able to identify novel regulatory pathways that allow organisms to adapt to different metabolic states. In addition to the genetic tools offered by Drosophila, we use genomics, proteomics and biochemistry to investigate these novel pathways in various cell types and organs such neurons and glia of the central nervous system.
Research
Chromatin, neuronal and behavioral plasticity
We aim to understand the transcriptional mechanisms and chromatin plasticity involved in behavioral plasticity. Many cognitive genetic diseases, such as Coffin-Lowry, Rubinstein-Taybi syndrome and ATRX mental retardation syndrome, are caused by mutations in genes encoding chromatin modifying and transcription factors. We have established tissue or cell type specific genome wide methods to monitor changes in gene expression and chromatin structure. These tools complement the other classic tools used to study transcription and chromatin.
Publications
Scientific vita
- since 2010
- Group leader, Dept. Physiol. Chemistry, Biomedical Center, LMU Munich
- 2007-2010
- Postdoctoral researcher, European Molecular Biology Laboratory, Heidelberg
- 1999-2005
- Postdoctoral researcher, Cold Spring Harbor Laboratory, USA
- 1997-1999
- Postdoctoral researcher, Michigan State University, USA
- 1997
- PhD in Biochemistry, Michigan State University, Advisor: John Kaguni