Rudelius Lab

Research

Using multiparametric single-cell analysis we study the pathogenesis and (immune-) biology of tumors. In the era of molecular and immune-targeting therapies understanding the crosstalk of tumor and tumor microenvironment (TME) is essential to determine treatment vulnerability and resistance. Therefore, our main focus is the analysis of the tumor and the TME such as tumor infiltrating lymphocytes (TILs) or cancer-associated fibroblasts (CAFs). We are convinced, that it is important to study tumor-microenvironment interactions at a spatial resolution and single cell level and not at bulk level.

We have implemented several single-cell analysis methods such as multispectral imaging, spatial transcriptomics, spatial metabolomics (collaboration Prof. Dr. A. Walch) and machine-learning-based computational analysis in our laboratory to analyse clinical routine (widely available) FFPE tissue.

The close exchange with clinical experts in the context of daily routine as well as national and international reference centers and networks (CCC (Clinical Cancer Center Munich); DKTK; EWOG MDS/SAA; ECNM), German Lymphoma Alliance (GLA); European MCL Network) guides our research and allows a transition of our results into the clinic.

With an deeper understanding of detailed tumor substructures and immune function we hope to improve the diagnosis and therapy for patients.

Publications

Pubmed