Merrow Lab Publications

Sartor F, Ferrero-Bordera B, Haspel J, Sperandio M, Holloway PM, Merrow M. Circadian Clock and Hypoxia. Circ Res. (2024) Mar 15;134(6):618-634. Pubmed

Sartor, F., Xu, X., Popp, T., Dodd, AN, Kovacs, AT, Merrow, M. The circadian clock of the bacterium B. subtilis evokes properties of complex, multicellular circadian systems. (2023) Sci Adv. Aug 4;9(31):eadh1308. doi: 10.1126/sciadv.adh1308.


Skapetze L, Owino S, Lo EH, Arai K, Merrow M, Harrington M. (2023) Rhythms in barriers and fluids: Circadian clock regulation in the aging neurovascular unit. Neurobiol Dis. Jun 1;181:106120. doi: 10.1016/j.nbd.2023.106120.

Klerman EB, Brager A, Carskadon MA, Depner CM, Foster R, Goel N, Harrington M, Holloway PM, Knauert MP, LeBourgeois MK, Lipton J, Merrow M, Montagnese S, Ning M, Ray D, Scheer FAJL, Shea SA, Skene DJ, Spies C, Staels B, St-Onge MP, Tiedt S, Zee PC, Burgess HJ. (2022) Keeping an eye on circadian time in clinical research and medicine. Clin Transl Med. Dec;12(12): e1131. doi: 10.1002/ctm2.1131.


Mata-Cabana A, Romero-Expósito FJ, Geibel M, Piubeli FA, Merrow M, Olmedo M. (2022) Deviations from temporal scaling support a stage-specific regulation for C. elegans postembryonic development. BMC Biol. Apr 27;20(1):94. doi: 10.1186/s12915-022-01295-2.


An Z, Piccoli B, Merrow M, Lee K. (2022) A Unified Model for Entrainment by Circadian Clocks: Dynamic Circadian Integrated Response Characteriatic (dCIRC). J Biol Rhythms. Apr;37(2):202-215. doi: 10.1177/07487304211069454.

Zerbini G, Merrow M, Winnebeck EC. (2021) Weekly and seasonal variation in the circadian melatonin rhythm in humans: A response. J Pineal Res. Oct 24:e12777. doi: 10.1111/jpi.12777. PubMed

Burt P, Grabe S, Madeti C, Upadhyay A, Merrow M, Roenneberg T, Herzel H, Schmal C. (2021) Principles underlying the complex dynamics of temperature entrainment by a circadian clock. iScience Oct 30;24(11):103370. doi: 10.1016/j.isci.2021.103370. eCollection 2021 Nov 19. PubMed

Herz, R.S., Herzog, E.D., Merrow, M., Noya, S.B. (2021) The circadian clock, the brain, and COVID-19: the cases of olfaction and the timing of sleep. J. Biol. Rhythms. August 15: https://doi.org/10.1177/07487304211031206. PubMed

An, Z., Piccoli, B., Merrow M. Lee, K. (2021) A Unified Model for Entrainment by Circadian Clocks: Dynamic Circadian Integrated Response Characteristic (dCiRC). bioRxiv

Boltze J, Didwischus N, Merrow M, Dallmann R, Plesnila N.J (2020) Circadian effects on stroke outcome - Did we not wake up in time for neuroprotection? Cereb Blood Flow Metab. Dec 18:271678X20978711. doi: 10.1177/0271678X20978711. Pubmed

Zerbini G, Winnebek E, Merrow M. (2021) Weekly, seasonal, and chronotype-dependent variation of dim-light melatonin onset. J Pineal Research. Pubmed

Haspel J, Kim M, Zee P, Schwarzmeier T, Montagnese S, Panda S, Albani A, Merrow M. (2021) A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care. J Biol Rhythms. Feb 11:748730421992587. Pubmed

Eelderink-Chen Z, Bosman J, Sartor F, Dodd AN, Kovács ÁT, Merrow M. (2021) Science Advances: A circadian clock in non-photosynthetic bacteria Sci Adv. Jan 8;7(2):eabe2086. doi: 10.1126/sciadv.abe2086. Pubmed

Merrow M., & Harrington, M. (2020). A functional context for heterogeneity of the circadian clock in cells. PLoS Biology, 18(10). Pubmed

Zerbini, G., van der Vinne, V., Otto, L. K. M., Monecke, S., Kantermann, T., & Merrow M. (2019). Tardiness Increases in Winter: Evidence for Annual Rhythms in Humans. Journal of Biological Rhythms. Pubmed

Sartor F, Eelderink-Chen Z, Aronson B, Bosman J, Hibbert LE, Dodd AN, Kovács ÁT, Merrow M. (2019) Are There Circadian Clocks in Non-Photosynthetic Bacteria? Biology (Basel). May 22;8(2). pii: E41. doi: 10.3390/biology8020041. Pubmed

Breit A, Miek L, Schredelseker J, Geibel M, Merrow M., Gudermann T. (2018) Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling. J Biol Chem. Nov 2;293(44):17278-17290. doi: 10.1074/jbc.RA118.004429. Epub 2018 Sep 14. Pubmed

Zerbini G, Kantermann T, Merrow M. (2018) Strategies to decrease social jetlag: Reducing evening blue light advances sleep and melatonin. Eur J Neurosci. Dec 2. doi: 10.1111/ejn.14293. Pubmed

Olmedo M, Roenneberg T, Merrow M., Corrochano LM. (2017) Glucose sensing and light regulation: A mutation in the glucose sensor RCO-3 modifies photoadaptation in Neurospora crassa. Fungal Biol. Jun;122(6):497-504. doi: 10.1016/j.funbio.2017.10.004. Epub 2017 Nov 4. Pubmed

Zerbini G, Merrow M. (2017) Time to learn: How chronotype impacts education. Psych J. Oct 10. doi: 10.1002/pchj.178. Pubmed

de Bekker, C., Will, I., Hughes, D.P., Brachmann, A. Merrow, M. (2017) Daily rhythms and enrichment patterns in the transcriptome of the behavior-manipulating parasite Ophiocordyceps kimflemingiae PLoSOne Nov 3;12(11):e0187170. doi: 10.1371/journal.pone.0187170. eCollection 2017. Pubmed

Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptáček LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB. Guidelines for Genome-Scale Analysis of Biological Rhythms. (2017) J Biol Rhythms Oct;32(5):380-393. doi: 10.1177/0748730417728663. Epub 2017 Nov 3. Pubmed

Olmedo M, Merrow M, Geibel M. (2017) Sleeping Beauty? Developmental Timing, Sleep, and the Circadian Clock in Caenorhabditis elegans. Adv Genet. 97:43-80. doi: 10.1016/bs.adgen.2017.05.001. Epub 2017 Jun 16. Pubmed

Roenneberg T, Merrow M. (2016) The Circadian Clock and Human Health. Curr Biol. May 23;26(10):R432-43. doi: 10.1016/j.cub.2016.04.011. Pubmed

Olmedo M., Geibel M., Artal-Sanz M., Merrow M. (2015). A High-Throughput Method for the Analysis of Larval Developmental Phenotypes in Caenorhabditis elegans. Genetics. Oct;201(2):443-8. doi: 10.1534/genetics.115.179242. Epub 2015 Aug 20. Pubmed

de Bekker C, Ohm RA, Loreto RG, Sebastian A, Albert I, Merrow M, Brachmann A, Hughes DP. (2015) Gene expression during zombie ant biting behavior reflects the complexity underlying fungal parasitic behavioral manipulation. BMC Genomics. Aug 19;16:620. doi: 10.1186/s12864-015-1812-x. Pubmed

van der Vinne V., Zerbini G., Siersema A., Pieper A., Merrow M., Hut R.A., Roenneberg T. and Kantermann T. (2015). Timing of examinations affects school performance differently in early and late chronotypes. J. Biol. Rhyth., 30(1):53-60. Pubmed

Eelderink-Chen, Z., Olmedo, M., Bosman, J., and Merrow M. (2015). Using circadian entrainment to find cryptic clocks. Methods in Enzymology, 551:73-93. Pubmed

de Bekker, C., Merrow M., and Hughes, D. P. (2014). From Behavior to Mechanisms: An Integrative Approach to the Manipulation by a Parasitic Fungus (Ophiocordyceps uni-lateralis s.l.) of Its Host Ants (Camponotus spp.). Integr. Comp. Biol. 54, 166-176.Pubmed

Olmedo, M., O'Neill, J.S., Edgar, R.S., Valekunja, U.K., Reddy, A.B., and Merrow M. (2012). Circadian regulation of olfaction and an evolutionarily conserved, nontranscriptional marker in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America 109, 20479-20484. Pubmed

Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O'Neill JS, Reddy AB. (2012) Peroxiredoxins are conserved markers of circadian rhythms. Nature 485(7399):459-64. doi: 10.1038/nature11088. Pubmed

Roenneberg T, Allebrandt KV, Merrow M, Vetter C. (2012) Social jetlag and obesity. Curr. Biol. 22(10):939-43. Pubmed

Ripperger J.A. and Merrow M. (2011) Perfect timing: epigenetic regulation of the circadian clock. FEBS Lett. 585(10):1406-11. Epub 2011 Apr 27. Pubmed

Rémi, J., Merrow M., Roenneberg, T. (2010) A circadian surface of entrainment: varying T, t and photoperiod in Neurospora crassa. J. Biol. Rhyth. 25(5):318-28. Pubmed

Roenneberg, T., Hut, R., Daan, S., Merrow, M (2010) Entrainment concepts revisited. J. Biol. Rhyth. 25(5):329-39. Pubmed

Roenneberg, T., Rémi, J., Merrow M. (2010) Modeling a circadian surface. J. Biol. Rhyth. 25(5):340-9. Pubmed

Froehlich, A.C., Chen C.H., Belden W.J., Madeti C., Roenneberg T., Merrow M., Loros J.J., Dunlap J.C. (2010) Genetic and molecular characterization of a cryptochrome from the filamentous fungus Neurospora crassa. Eukaryot. Cell 9(5):738-50. Pubmed

Eelderink-Chen, Z., Mazzotta, G., Sturre, M., Bosman, J., Roenneberg, T., and Merrow M. (2010). A circadian clock in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America 107, 2043-2047. Pubmed

Allebrandt, K.V., Teder-Laving, M., Akyol, M., Pichler, I., Müller-Myhsok, B., Pramstaller, P., Merrow M., Meitinger, T., Metspalu, A., Roenneberg, T. (2010) CLOCK gene variants associate with sleep duration in two independent populations. J. Biol. Psych. doi:10.1016/j.biopsych.2009.12.026. Pubmed

Merrow M. and Maas, M.F.P.M. (2009) Circadian clocks: evolution in the shadows. Curr. Biol. 19(22):R1042-5. Pubmed

Brunner, M., Simons, M., and Merrow M. (2008) Lego clocks: building a clock from parts. Genes and Development 22:1422-1426; doi:10.1101/gad.1686608. Pubmed

Brunner, M. and Merrow M. (2008) The green yeast uses its plant-like clock to regulate its animal-like tail. Genes and Development 22:825-831; doi:10.1101/gad.1664508. Pubmed

Roenneberg, T., Kuehnle, T., Juda, M., Kanterrmann, T., Allebrandt, K., Gordijn, M., and Merrow M. (2007) Epidemiology of the human circadian clock. Sleep Med. Rev. 11(6): 429-438. Pubmed

Kantermann, T., Juda, M., Merrow M. and Roenneberg, T. (2007) The human circadian clock's seasonal adjustment is disrupted by daylight saving time. Curr. Biol. 17(22): 1996-2000. Pubmed

Merrow M. and Roenneberg, T. (2007) Circadian clock: Time for a phase shift of ideas? Current Biology 17(16):R636-638. Pubmed

Roenneberg, T., Kumar, C.J. and Merrow M. (2007) The circadian clock of homo sapiens entrains to sun time. Current Biology 17:R44-R45. Pubmed

Sveric, K., Mason, M., Roenneberg, T. and Merrow M. (2007) Novel strategies for identification of clock genes in Neurospora using insertional mutagenesis. Methods Mol. Biol. 362:173-185. Pubmed

Merrow M., Mazzotta, G., Chen, Z. and Roenneberg, T. (2006) The right place at the right time: the regulation of daily timing by phosphorylation. Genes and Development 20:2629-2623. Pubmed

Wittman, M., Dinnich, J., Merrow M. and Roenneberg, T. (2006) Social jetlag: misalignment of biological and social time. Chronobiology International 23: 71-80. Pubmed

Roenneberg, T. & Merrow M. (2005) Circadian clocks - the fall and rise of physiology. Nature Reviews Molecular and Cell Biology 6:965-971. Pubmed

Merrow M., Boesl, C. and Roenneberg, T. (2005) Cellular clocks: circadian rhythms in primary human fibroblasts. J. Biosci. 30:101-103. Pubmed

Merrow M., Spoelstra, K. & Roenneberg, T. (2005) The circadian cycle: daily rhythms from behaviour to genes. EMBO Reports 6:930-935. Pubmed

Diernfellner, A.C.R., Schafmeier, T., Merrow M.W. & Brunner, M. (2005) Mo-lecular mechanism of temperature sensing by the circadian clock of Neurospora crassa. Genes and Development doi:10.1101/gad.345905. Pubmed

Roenneberg, T. & Merrow M. (2005) Circadian Clocks: Translation Lost. Cur-rent Biology 15: R470-R473. Pubmed

Roenneberg, T., Dragovic, Z. and Merrow M. (2005) Demasking biological oscillators: Properties and principles of entrainment exemplified by the Neurospora circadian clock. Proc. Natl. Acad. Sci. 102:7742-7747. Pubmed

Roenneberg, T., Kuehnle, T., Pramstaller, P.P., Ricken, J., Havel, M., Guth, A. & Merrow M. (2004) A marker for the end of adolescence. Current Biology 14:1038-1039. Pubmed

Tan,Y., Merrow M. & Roenneberg, T. (2004) Photoperiodism in Neurospora. Journal of Biological Rhythms (19: 135-43). Pubmed

Tan,Y., Dragovic, Z., Roenneberg, T. & Merrow M. (2004). Entrainment disso-ciates transcription and translation of a circadian clock gene in Neurospora. Cur-rent Biology 14:433-438. Pubmed

Merrow M, Dragovic, Z, Tan, Y., Meyer, G., Sveric, K., Mason, M., Ricken, J. & Roenneberg, T. (2003) Combining theoretical and experimental approaches to understand the circadian clock. Chronobiology International 20:559-575. Pubmed

Roenneberg, T., Daan, S. & Merrow M. (2003). The art of entrainment. Journal of Biological Rhythms. 18:183-194. Pubmed

Roenneberg, T. & Merrow M. (2003). The network of time: understanding the molecular circadian system. Current Biology 13:R198-R207. Pubmed

Roenneberg, T., Wirz-Justice A. & Merrow M. (2003). Life between clocks – daily temporal patterns of human chronotypes. Journal of Biological Rhythms. 18:80-90. Pubmed

Roenneberg, T. & Merrow M. (2002). Life before the Clock: Modeling Circadi-an Evolution. Journal of Biological Rhythms. 17:495-505. Pubmed

Dragovic, Z., Tan, Y., Goerl, M., Roenneberg, T. & MerrowPubmeM. (2002). Circadi-an behavior and light reception in "clock-less" and “blind” mutants of Neurospo-ra crassa. EMBO Journal. 21: 3643-3651. Pubmed

Daan, S., Merrow M., Roenneberg, T.: External Time – Internal Time. J. Biol. Rhythms 17: 107-109 (2002). Pubmed

Goerl, M., Merrow M., Huttner, B., Johnson, J., Roenneberg, T. & Brunner, M. (2001). A PEST-like element in FREQUENCY determines the length of the circa-dian period in Neurospora crassa. EMBO Journal. 20: 7074. Pubmed

Roenneberg, T. and M. Merrow (2001) Circadian systems - different levels of complexity. Philosophical Transactions of the Royal Society, London. 356: 1687-1696. Pubmed

Bell-Pedersen, D., M. Merrow S. Crosthwaite and P. Lakin-Thomas (2001) The Fungal Circadian Clock -- simple or complex? Phil. Trans. Royal Soc. Lond. 356: 1697-1709. Pubmed

Merrow M., T. Roenneberg, G. Macino and L. Franchi (2001) A fungus among us: The Neurospora circadian system. Seminars in Cell and Developmental Biology, 12:279-286. Pubmed

Roenneberg, T. and M. Merrow (2001) Seasonality and photoperiodism in fungi. Journal of Biological Rhythms, 16:403-414. Pubmed

Merrow M. and T. Roenneberg (2001) Circadian Clocks: Running on Redox. Cell, 106: 141-144. Pubmed

Merrow M., L. Franchi, Z. Dragovic, M. Görl, J. Johnson, M. Brunner, G. Macino and T. Roenneberg (2001) Circadian regulation of the light input pathway in Neurospora crassa. EMBO Journal, 20: 307-315. Pubmed

Merrow M. and T. Roenneberg (2001) The circadian cycle: is the whole greater than the sum of its parts? Trends in Genetics, 17: 4-7. Pubmed

Roenneberg, T. and M. Merrow (2000) Circadian light input: omnes viae Romam ducunt. Current Biology, 10: R742-R745. Pubmed

Roenneberg, T. and M. Merrow (1999) Circadian clocks and metabolism. Jour-nal of Biological Rhythms. 14: 17-27.. Pubmed

Roenneberg, T. and M. Merrow (1999) Circadian clocks - from genes to com-plex behaviour. Reprod., Nutr. Dev. 39: 277-294. Pubmed

Merrow M., M. Brunner and T. Roenneberg (1999) Assignment of circadian function for the Neurospora clock gene frequency. Nature. 399: 584-586. Pubmed

Liu, Y., M. Merrow J. L. Loros and J. C. Dunlap (1998) How Temperature Changes Reset a Circadian Oscillator. Science. 281: 825-829. Pubmed

Roenneberg, T. and M. Merrow (1998) Molecular circadian oscillators - an alter-native hypothesis. Journal of Biological Rhythms. Pubmed

Roenneberg, T., M. Merrow and B. Eisensamer (1998) Cellular mechanisms of circadian systems. Zoology. 100: 273-286.

Merrow M., N. Garceau and J. Dunlap (1997) Dissection of a circadian oscilla-tion into discrete domains. Proc. Natl. Acad. Sci., USA. 94: 3877-3882. Pubmed

Dunlap, J., J. Loros, M. Merrow S. Crosthwaite, D. Bell-Pedersen, N. Garceau, M. Shinohara, H. Cho and C. Luo (1996) The genetic and molecular dissection of a prototypic circadian system. Prog. Brain Res. 111: 11-27. Pubmed

Merrow, M. W. and J. C. Dunlap (1994) Intergeneric complementation of a circadian rhythmicity defect: phylogenetic conservation of structure and function of the clock gene frequency. EMBO J. 13: 2257-2266. Pubmed

Merrow, M.W., and B.T. Huber. (1991). rIL-4 differentially regulates rIL-2-induced murine NK and LAK killing in CD8+ and CD8- precursor cell subsets. International Immunology 3: 551-561. Pubmed

Munoz, E., A.M. Zubiaga, M. Merrow N.P. Sauter and B.T. Huber. (1990). Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: Role of cAMP in T cell proliferation. Journal of Experimental Medicine 172: 95-103. Pubmed

Zubiaga, A.M., E. Munoz, M. Merrow and B.T. Huber. (1990). Regulation of interleukin 6 production in T helper cell subsets. International Immunology 2: 1047-1054. Pubmed

Rothman, B.L., M. Merrow, A. Despins, T. Kennedy and D.L. Kreutzer. (1989). Effect of lipopolysaccharide on C3 and C5 production by human lung cells. Journal of Immunology 143: 196-202. Pubmed

Rothman, B.L., M. Merrow M. Bamba, T. Kennedy and D.L. Kreutzer. (1989). Biosynthesis of the Third and Fifth Complement Components by Isolated Human Lung Cells. American Review of Respiratory Disease 139: 212-220. Pubmed

Kennedy, T.L., M. Merrow S.M. Phillips, M. Norman, and E.G. Neilson. (1985). Macrophage chemotaxis in anti-tubular basement membrane-induced interstitial nephritis in guinea pigs. Clinical Immunology and Immunopathology 36: 243-248. Pubmed

Kowalski, L.A., A.W. Walsh, M. Merrow W. Paulekus, W. Mackin and J.A. Grasso. (1984). Characterization and comparative immunoreactivity of antibody to newt (T. cristatus) globins. Comparative Biochemistry and Physiology 78: 393-399. Pubmed

Steinsson, K., R.H. McLean, M. Merrow N.F. Rothfield and A. Weinstein. (1983). Selective complete C1q deficiency associated with systemic lupus erythematosus. Journal of Rheumatology 10: 590-594. Pubmed