AG Kaiser

Affiliation: LMU Munich – Department of Medicine I / Cardiology Research Focus: AG Kaiser investigates the mechanisms linking thrombosis, inflammation, and cardiovascular immunology—particularly how platelets and innate immune cells like neutrophils interact during vascular inflammation to influence disease outcomes. Role in ICON: Within ICON, AG Kaiser contributes to decoding immunothrombotic processes that underlie vascular inflammation and cardiovascular disease, helping to connect molecular insights with translational and clinical strategies. Key Areas of Work: • Immunothrombosis & Thromboinflammation Dissecting molecular triggers that switch immunothrombotic mediators from protective to harmful during inflammation. • Procoagulant Platelet Activation Investigating platelet ballooning, phosphatidylserine exposure, and their dual roles in host defense versus thrombosis. • Immune Phenotyping of Cardiovascular Diseases Combining clinical patient phenotyping, multi-omics approaches, tailored in vitro approaches, and translational murine models to dissect cellular and molecular mediators of CV diseases like infective endocarditis and cardiogenic shock Techniques & Infrastructure: • Single-cell RNA sequencing & proteomics • Translational murine disease models • Intravital microscopy for real-time visualization of cell-cell interactions • Functional in vitro assays