Paper of the Month

Every month, we highlight two recent publications in particularly prestigious journals in the categories "Original Article" and "Review" with first or last authorship by members of the Medical Faculty and LMU Hospital. The Dean of Research congratulates them on their outstanding publications.

Scientists from the Faculty of Medicine and LMU Hospital who have recently published articles in particularly prestigious journals in the categories "Original Article" and "Review" as first or last author are cordially invited to submit their work as a proposal for Paper of the Month to Dr. Dorothee Hodde in the Office of the Dean of Research: Dorothee.Hodde@med.uni-muenchen.de.

Dezember 2025

Original work December 2025: de la Rosa C, Kendirli A, Baygün S, Bauernschmitt F, Thomann A S, Kisioglu I, Beckmann D, Carpentier Solorio Y, Pfaffenstaller V, Tai Y H, Mehraein N, Sanchez P, … Kerschensteiner M;
# Contributed equally.

In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation
journal: Lancet Infectious Diseases 2025 (JIF 20.0)
first author: Clara de la Rosa del Val
Institute of Clinical Neuroimmunology
first author: Dr. Arek Kendirli
Institute of Clinical Neuroimmunology

Review December 2025: Fu W, Ishikawa-Ankerhold H, Gaertner F

Homeostasis of megakaryocytes: balancing tissue residency and consumptive platelet production
journal: Trends Cell Biol. 2025 (JIF 18.1)
first author: Dr. Wenwen Fu
Department of Medicine I
last author: Professor Florian Gärtner
Department of Medicine I

November 2025

Original work November 2025: Heinrich N, Manyama C, Koele S E, Mpagama S, Mhimbira F, Sebe M, Wallis R S, Ntinginya N, Liyoyo A, Huglin B, Minja L T, Wagnerberger L, … Svensson E M; PanACEA consortium

Sutezolid in combination with bedaquiline, delamanid, and moxifloxacin for pulmonary tuberculosis (PanACEA-SUDOCU-01): a prospective, open-label, randomized, phase 2b dose-finding trial
journal: Lancet Infectious Diseases 2025 (JIF 31.0)
first author: Dr. Norbert Heinrich
Institute for Infectious Diseases and Tropical Medicine

Review November 2025: Chubanov V, Grimm C, Hill K, Schaefer M, Köttgen M, Storch U, Mederos Y Schnitzler M, Kudrina V, Erbacher A, Gudermann T

Physiological functions and pharmacological targeting of transient receptor potential channels
journal: Eur Heart J. 2025 (JIF 17.3)
first author: Vladimir Chubanov
Walther Straub Institute of Pharmacology and Toxicology
last author: Prof. Dr. Thomas Gudermann
Walther Straub Institute of Pharmacology and Toxicology

October 2025

Original work October 2025: Nowak E, Zhang Q, Zhang S, Zhao Y, Ye H, Machado M, Moises C, Tóth M, Stark J, Yuen K, Gurnell M, MacFarlane J, … Reincke M

Cycle characterization and clinical complications in patients with cyclic Cushing's syndrome: insights from an international retrospective cohort study
journal: Lancet Diabetes Endocrinol 2025 (JIF 41.8)
first author: Dr. Elisabeth Nowak
Department of Medicine IV
last author: Professor Martin Reincke
Department of Medicine IV

Review October 2025: Soehnlein O, Lutgens E, Döring Y

Distinct inflammatory pathways shape atherosclerosis in different vascular beds
journal: Eur Heart J. 2025 (JIF 35.6)
last author: Prof. Dr. Yvonne Döring
Institute of Cardiovascular Prevention

September 2025

Original work September 2025: Herrmann F E M, Jeppsson A, Kirov H, Charitos E I, Dacian D, Brömsen J, Massberg S, Sadoni S, Doenst T, Juchem G, Hagl C

Long-Term Continuous Monitoring of New-Onset Atrial Fibrillation After Coronary Artery Bypass Grafting
journal: JAMA 2025 (JIF 55.0)
first author: Dr. Florian Herrmann
Department of Cardiac Surgery
last author: Prof. Dr. Christian Hagl
Department of Cardiac Surgery

Review September 2025: Kaiser R, Anjum A, Nicolai L.

Platelet heterogeneity in disease: the many and the diverse?
journal: Blood 2025 (JIF 23.1)
first author: Dr. Rainer Kaiser
Department of Medicine I
final authors: Dr. Leo Nicolai
Department of Medicine I

August 2025

Original work August 2025: Graeser M, Gluz O, Zu Eulenburg C, Kuemmel S, von Schumann R, Christgen M, Wuerstlein R, Pelz E, Heinrich Kreipe H, Schmid P, Thill M, L Braun M, Potenberg J, Schumacher C, Tio J, Schumacher J, Wujak L, D Hartkopf A, Just M, Schem C, Luedtke-Heckenkamp K, Hilpert F, Kentsch A, Kates R E, Nitz U, Harbeck N

Prediction of survival after de-escalated neoadjuvant therapy in HER2+ early breast cancer: A pooled analysis of three WSG trials
journal: Ann Oncol 2025 (JIF 65.4)
last author: Professor Nadia Harbeck
Department of Obstetrics and Gynecology

Review August 2025: Boehmer D, Zanoni I

Interferons in health and disease
Journal: Cell 2025 (JIF 42,5)
first author: Dr. Daniel Boehmer
Department of Clinical Pharmacology

July 2025

Original work July 2025: Bernhardt A M, Rodríguez-Baz Í, Aldecoa I, Arranz J, Arriola-Infante J E, Maure-Blesa L, Carmona-Iragui M, Longen S, Trossbach S V, Giese A, Matthias T, Benejam B, Videla L, Del Hoyo Soriano L, Barroeta I, Sanjuan A, Fernández S, Vaqué-Alcázar L, Rozalem Aranha M, Morcillo-Nieto A O, Nübling G, Wagemann O, Stockbauer A, Tondo M, Bejanin A, Lleó A, Alcolea D, Molina-Porcel L, Fortea J, Levin J

Alpha-synuclein co-pathology in Down syndrome-associated Alzheimer's disease
journal: Alzheimer's Dement. 2025 (JIF 11.1)
first author: Dr. Alexander Bernhardt
Department of Neurology
last author: Prof. Johannes Levin, MD
Department of Neurology

Original work Review 2025: Rejeski K, Hill J A, Dahiya S, Jain M D

Noncanonical and mortality-defining toxicities of CAR T cell therapy
journal: Nat Med. 2025 (JIF 50.0)
first author: Dr. Kai Rejeski
Department of Medicine II

June 2025

Original Article June 2025: Petrozziello E, Sayed A, Freitas JA, Federle C, Nedjic J, Ravens S, Akçabozan B, Schulz AM, Zehn D, ..., Daley SR#, Klein L#

# Contributed equally

Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells
journal: Nat Immunology 2025 (JIF 27.6)
first author: Dr. Elisabetta Petrozziello
Institute for Immunology
last author: Prof. Dr. Ludger Klein
Institute for Immunology

Review May 2025: Trefny MP, Kroemer G, Zitvogel L, Kobold S

Metabolites as agents and targets for cancer immunotherapy
journal: Nat Rev Drug Discov (JIF 101.8)
first author: Dr. Marcel Trefny
Department of Clinical Pharmacology
last author: Prof. Dr. Sebastian Kobold
Department of Clinical Pharmacology

May 2025

Original Article May 2025: Bonfiglio CA #, Lacy M #, Triantafyllidou V, Farina FM, Janjic A, Nitz K, Wu Y, Bazioti V, Avcilar-Kücükgöze I, ..., Lutgens E #, Atzler D #

# Contributed equally
Ezh2 shapes T cell plasticity to drive atherosclerosis
journal: Circulation 2025 (JIF 38.6)
first author: Dr. Cecilia Bonfiglio
Institute of Cardiovascular Prevention
last authors: Prof. Dr. Esther Lutgens
Institute of Cardiovascular Prevention
: PD Dr. Dorothee Atzler
Institute of Cardiovascular Prevention

Review May 2025: Albert NL, Galldiks N, Ellingson BM, van den Bent MJ, Chang SM, Cicone F, Koh E, Law I Le Rhun E, ..., Preusser M

RANO criteria for response assessment of brain metastases based on amino acid PET imaging
journal: Nat Med 2025 (JIF 50.0)
first author: Prof. Dr. Nathalie Albert
Department of Nuclear Medicine

April 2025

Original Article April 2025: Gottschlich A #, Grünmeier R #, Hoffmann GV #, Nandi S #, Kavaka V, Müller PJ, Jobst J, Oner A, Kaiser R,..., Endres S, Kobold S

# Contributed equally

Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma
journal: Blood 2025 (JIF 21.1)
first authors: Dr. Adrian Gottschlich
Department of Medicine III and Department of Clinical Pharmacology
: Ruth Grünmeier
Department of Clinical Pharmacology
: Gordon Victor Hoffmann
Department of Clinical Pharmacology
: Dr. Sayantan Nandi
Department of Clinical Pharmacology
last author: Prof. Dr. Sebastian Kobold
Department of Clinical Pharmacology

Review April 2025: Klingl YE #, Petrauskas A, Jaślan D #, Grimm C

# Contributed equally

TPCs: from plant to human
journal: Physiol Rev 2025 (JIF 33.4)
first authors: Dr. Yvonne Eileen Klingl
Walther Straub Institute of Pharmacology and Toxicology
: Dr. Dawid Jaslan
Walther Straub Institute of Pharmacology and Toxicology
last author: Prof. Dr. Christian Grimm
Walther Straub Institute of Pharmacology and Toxicology

March 2025

Original Article March 2025: Linder A #, Nixdorf D#, Kuhl N, Piseddu I, Xu T, Holtermann A V, Kuut G, Endres R, Philipp N, Bücklein V, de Graaff J, Carell T, Kobold S, Kischel R, Hornung V #, Subklewe M#

# Contributed equally

STING activation improves T-cell-engaging immunotherapy for acute myeloid leukemia
journal: Blood 2025 (JIF 21.1)
first author: Dr. Andreas Linder
Department of Medicine II
last author: Prof. Dr. Marion Subklewe
Department of Medicine III

Review March 2025: Schwarzlmueller P, Triebig A, Assié G, Jouinot A, Theurich S, Maier T, Beuschlein F, Kobold S, KroissM

Steroid hormones as modulators of anti-tumor immunity
journal: Nat Rev Endocrinol 2025 (JIF 31.0)
first author: Dr. Paul Schwarzlmueller
Department of Medicine IV
last author: Prof. Dr. Matthias Kroiß
Department of Medicine IV

February 2025

Original Article February 2025: Stintzing S #, Klein-Scory S #, Fischer von Weikersthal L, Fuchs M, Kaiser F, Heinrich K, Modest D P, Hofheinz R, Decker T, Gerger A, Angermeier S, Rumpold H, [ ... ] Baraniskin A #, Heinemann V#

# Contributed equally

Baseline liquid biopsy in relation to tissue-based parameters in metastatic colorectal cancer: results from the randomized FIRE-4 (AIO-KRK-0114) study
journal: J Clin Oncol 2025 (JIF 42.1)
last author: Prof. Dr. Volker Heinemann
Department of Medicine III

Review February 2025: Silkenstedt E und Dreyling M

Treatment of relapsed/refractory mantle cell lymphoma
journal: Blood 2025 (JIF 21.1)
first author: Dr. Elisabeth Silkenstedt
Medical Clinic and Polyclinic III
last author: Prof. Dr. Martin Dreyling
Medical Clinic and Polyclinic III

January 2025

Original Article January 2025: Asare Y #, Yan G #, Schlegl C, Prestel M, Van der Vorst E P C, Teunissen A J P, Aronova A, [ ... ], Bernhagen J, Dichgans M

# Contributed equally

A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis
journal: Immunity 2025 (JIF 25.5)
first author: Dr. Yaw Asare
Institute for Stroke and Dementia Research (ISD)
last author: Prof. Dr. Martin Dichgans
Institute for Stroke and Dementia Research (ISD)

Review January 2025: Klein L and Petrozziello E

Antigen presentation for central tolerance induction
journal: Nat Rev Immunol 2025 (JIF 67.3)
first author: Prof. Dr. Ludger Klein
Institute for Immunology
last author: Dr. Elisabetta Petrozziello
Institute for Immunology

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Original work March 2024: J Hausleiter, M Lachmann, L Stolz, F Bedogni, A P Rubbio, R Estévez-Loureiro, S Raposeiras-Roubin, P Boekstegers, N Karam, V Rudolph; EuroSMR

Investigators# Contributed equally

Artificial intelligence-derived risk score for mortality in secondary mitral regurgitation treated by transcatheter edge-to-edge repair: the EuroSMR risk score
journal: Eur Heart J 2024 (JIF 39.3)
first author: Prof. Dr. Jörg Hausleiter
Medical Clinic and Polyclinic I

Review March 2024: E Lüsebrink, L Binzenhöfer, D Hering, L Villegas Sierra, B Schrage, C Scherer, W S Speidl, A Uribarri, M Sabate, M Noc, E Sandoval, ... , M Orban, H Thiele ##

Contributed equally

Scrutinizing the role of venoarterial extracorporeal membrane oxygenation: has clinical practice outpaced the evidence?
journal: Circulation 2024 (JIF 37.8)
first author: PD Dr. Dr. Enzo Lüsebrink
Medical Clinic and Polyclinic I
first author: Dr. Leonhard Binzenhöfer
Medical Clinic and Polyclinic I
last author: Prof. Dr. Martin Orban
Medical Clinic and Polyclinic I

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Original work February 2024: S Frenz-Wiessner, S D Fairley, M Buser, I Goek,K Salewskij, G Jonsson,D Illig, B Zu Putlitz, D Petersheim, Y Li, P-H Chen, M Kalauz,... ,C Klein

Generation of complex bone marrow organoids from human induced pluripotent stem cells
journal: Nat Methods 2024 (JIF 48.0)
first author: Dr. Stephanie Frenz-Wießner
Children's Hospital and Children's Polyclinic at Dr. von Hauner Children's Hospital
last author: Prof. Dr. Christoph Klein
Children's Hospital and Children's Polyclinic at Dr. von Hauner Children's Hospital

Review February 2024: J Trebicka, R Hernaez, D L Shawcross, A L Gerbes

Recent advances in the prevention and treatment of decompensated cirrhosis and acute-on-chronic liver failure (ACLF) and the role of biomarkers
journal: Good 2024 (JIF 24.5)
last author: Prof. Alexander Gerbes
Medical Clinic and Polyclinic II

Original work January 2024: M. Dreyling, N. H. Fowler, M. Dickinson, J. Martínez-López, A. Kolstad, J. Butler, M. Ghosh, L. Popplewell, J. C. Chavez, E. Bachy, K. Kato, H. Harigae, ... , S. J. Schuster

Durable response after tisagenlecleucel in adults with relapsed/refractory follicular lymphoma: ELARA trial update
journal: Blood 2024 (JIF 20.3)
first author: Prof. Dr. Martin Dreyling
Medical Clinic and Polyclinic III

Review January 2024: M Becker, S M Dirschl, M G Scherm, I Serr , C Daniel

Niche-specific control of tissue function by regulatory T cells—Current challenges and perspectives for targeting metabolic disease
journal: Cell Metab 2024 (JIF 29.0)
last author: Professor Carolin Daniel
Department of Clinical Pharmacology

Original work December 2023: S Sirko, C Schichor, P Della Vecchia, F Metzger, G Sonsalla, T Simon, M Bürkle, S Kalpazidou, J Ninkovic, G Masserdotti, J Sauniere, V Iacobelli, ... ,J Tonn, M Götz

Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
journal: Nat Med 2023 (JIF 82.9)
first author: Dr. Svetlana Sirko
Chair of Physiological Genomics, Biomedical Center (BMC)
last author: Professor Magdalena Götz
Chair of Physiological Genomics, Biomedical Center (BMC)

Review December 2023: S Eustermann, A B Patel, K Hopfner, Y He,P Korber

contributed equally

Energy-driven genome regulation by ATP-dependent chromatin remodellers
journal: Nat Rev Mol Cell Biol 2023 (JIF 112.7)
last author: Prof. Dr. Philipp Korber
Chair of Molecular Biology, Biomedical Center (BMC)

Original work November 2023: A Kendirli, C de la Rosa, K F Lämmle, K Eglseer, I J Bauer, V Kavaka, S Winklmeier, L Zhuo, C Wichmann, L A Gerdes, T Kümpfel, ... , M Kerschensteiner, N Kawakami

# contributed equally

A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model
journal: Nat Neurosci. 2023 (JIF 25.0)
first author: Arek Kendirli
Institute for Clinical Neuroimmunology
first author: Clara de la Rosa
Institute for Clinical Neuroimmunology
first author: Katrin F Lämmle
Institute for Clinical Neuroimmunology
last author: Prof. Dr. Martin Kerschensteiner
Institute for Clinical Neuroimmunology
last author: Dr. Naoto Kawakami
Institute for Clinical Neuroimmunology

Review November 2023: K Schlepckow, E Morenas-Rodríguez, S Hong, C Haass

Stimulation of TREM2 with agonistic antibodies—an emerging therapeutic option for Alzheimer's disease
journal: Lancet Neurol. 2023 (JIF 48.0)
last author: Prof. Dr. Dr. Christian Haass
Chair of Metabolic Biochemistry, Biomedical Center (BMC)

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Original work October 2023: M Pruenster, R Immler, J Roth, T Kuchler, T Bromberger, M Napoli, K Nussbaumer, I Rohwedder, L M Wackerbarth, C Piantoni, K Hennis, ..., P Broz, M Sperandio

# contributed equally

E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation
journal: Nat Immunol. 2023 (JIF 30.5)
first author: Dr. Monika Prünster
Institute for Cardiovascular Physiology and Pathophysiology at the Walter Brendel Center for Experimental Medicine
first author: Dr. Roland Immler
Institute for Cardiovascular Physiology and Pathophysiology at the Walter Brendel Center for Experimental Medicine

last author: Prof. Dr. Markus Sperandio
Institute for Cardiovascular Physiology and Pathophysiology at the Walter Brendel Center for Experimental Medicine

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Original work September 2023: T Zhao, I Markevych, E Fuertes, K de Hoogh, S Accordini, A Boudier, L Casas, B Forsberg, J G Aymerich, M Gnesi, M Holm, ..., J Heinrich

Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults
journal: Lancet Reg Health Eur. 2023 (JIF 20.9)
first author: Dr. Tianyu Zhao
Institute and Polyclinic for Occupational, Social, and Environmental Medicine
last author: Dr. Joachim Heinrich
Institute and Polyclinic for Occupational, Social, and Environmental Medicine

Review October 2023: V Chubanov, M Köttgen, R M Touyz, T Gudermann

TRPM channels in health and disease
journal: Nat Rev Nephrol. 2023 (JIF 41.5)
first author: Dr. Vladimir Chubanov
Walther Straub Institute for Pharmacology and Toxicology
last author: Prof. Dr. Thomas Gudermann
Walther Straub Institute for Pharmacology and Toxicology

Review September 2023: R Kaiser, R Escaig, L Nicolai

Hemostasis without clot formation - how platelets protect the vasculature in inflammation, infection, and malignancy
journal: Blood. 2023 (JIF 20.3)
first author: Dr. Rainer Kaiser
Medical Clinic and Polyclinic I
last author: Dr. Leo Nicolai
Medical Clinic and Polyclinic I

Original work August 2023: Pekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionísio F, ...,Massberg S, Stark K

Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation
journal: Immunity. 2023 (JIF 32.4)
first author: Dr. Kami Pekayvaz
Medical Clinic and Polyclinic I
last author: Prof. Dr. Konstantin Stark
Medical Clinic and Polyclinic I

Review August 2023: Vogel JW, Corriveau-Lecavalier N, Franzmeier N, Pereira JB, Brown JA, Maass A, Botha H, Seeley WW, Bassett DS, Jones DT, Ewers M

Connectome-based modeling of neurodegenerative diseases: towards precision medicine and mechanistic insight
journal: Nat Rev Neurosci. 2023 (JIF 34.7)
last author: Prof. Dr. Michael Ewers
Institute for Stroke and Dementia Research (ISD)

Original work July 2023: Burkhardt G, Kumpf U, Crispin A, Goerigk S, Andre E, Plewnia C, Brendel B, Fallgatter A, Langguth, Abdelnaim M, Hebel T, Normann, ..., Padberg F

Transcranial direct current stimulation as an additional treatment to selective serotonin reuptake inhibitors in adults with major depressive disorder in Germany (DepressionDC): a triple-blind, randomized, sham-controlled, multicenter trial
journal: Lancet. 2023 (JIF 168.9)
first author: Dr. Gerrit Burkhardt
Clinic for Psychiatry and Psychotherapy
last author: Prof. Dr. Frank Padberg
Department of Psychiatry and Psychotherapy

Review July 2023: Nowak E, Vogel F, Albani A, Braun L, Rubinstein G, Zopp S, Ritzel K, Beuschlein F, Theodoropoulou M, Reincke M

Diagnostic challenges in cyclic Cushing's syndrome: a systematic review
journal: Lancet Diabetes Endocrinol. 2023 (JIF 44.5)
first author: Dr. Elisabeth Nowak
Medical Clinic and Polyclinic IV
last author: Prof. Dr. Martin Reincke
Medical Clinic and Polyclinic IV

Review June 2023: Köglsperger T, Rumpf S, Schließer P, Struebing FL, Brendel M, Levin J, Trenkwalder C, Höglinger GU #, Herms J##

Contributed equally.

Neuropathology of incidental Lewy body & prodromal Parkinson's disease
journal: Mol Neurodegener. 2023 (JIF 15.10)
first author: Dr. Thomas Köglsperger
Neurological Clinic and Polyclinic
last author: Prof. Dr. Günter Höglinger
Department of Neurology
last author: Prof. Dr. Jochen Herms
Max von Pettenkofer Institute
Institute of Neuropathology

Review May 2023: Weber C, Habenicht AJR, von Hundelshausen P

Novel mechanisms and therapeutic targets in atherosclerosis: inflammation and beyond
journal: Eur Heart J. 2023 (JIF 35.9)
first author: Prof. Dr. Christian Weber
Institute for Prevention and Epidemiology of Cardiovascular Diseases
last author: Dr. Philipp von Hundelshausen
Institute for Prevention and Epidemiology of Cardiovascular Diseases

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Original work April 2023: Thienel M#, Müller-Reif JB#, Zhang Z #, Ehreiser V, Huth J, Shchurovska K, Kilani B, Schweizer L, Geyer PE, Zwiebel M, Novotny J , … , Massberg S, Petzold T#

Contributed equally.

Immobility-associated thromboprotection is conserved across mammalian species from bear to human
journal: Science.2023 (JIF 56.9)
first author: Dr. Manuela Thienel
Medical Clinic and Polyclinic I
first author: Dr. Zhe Zhang
Medical Clinic and Polyclinic I

last author: Dr. Tobias Petzold
Medical Clinic and Polyclinic I

Review April 2023: Malfertheiner P, Camargo MC, El-Omar E, Liou J, Peek R, Schulz C, Smith SI, Suerbaum S

Helicobacter pylori infection
journal: Nat Rev Dis Primers. 2023 (JIF 81.5)
first author: Prof. Dr. Dr. Peter Malfertheinert
Department of Radiology
last author: Prof. Dr. Sebastian Suerbaum
Chair of Medical Microbiology and Hospital Hygiene,
Max von Pettenkofer Institute,

Original work March 2023: Gottschlich A, Thomas M, Grünmeier R, Lesch S, Rohrbacher L, Igl V, Briukhovetska D, Benmebarek MR, Vick B, Dede S, Müller K, …, Kobold S

Contributed equally.

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia
journal: Nat Biotechnol 2023 (JIF 68.16)
first author: Dr. Adrian Gottschlich
Department of Clinical Pharmacology
first author: Ruth Grünmeier
Department of Clinical Pharmacology
last author: Prof. Dr. Sebastian Kobold
Department of Clinical Pharmacology

Originalarbeit Februar 2023: Linder MI, Mizoguchi Y, Hesse S, Csaba G, Tatematsu M, Łyszkiewicz M, Ziȩtara N, Jeske T, Hastreiter M, Rohlfs M, Liu Y,Grabowski P, … , Klein C

Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes
Journal: Blood 2023 (JIF 25,67)
Erstautorin: Dr. Monika Linder
Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital
Letztautor: Prof. Dr. Christoph Klein
Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital

Review February 2023: Reichart B, Cooper DKC, Längin M, Tönjes RR, Pierson RN, Wolf E

Cardiac xenotransplantation: from concept to clinic
journal: Cardiovasc Res. 2023 (JIF 14.24)
first author: Prof. Dr. Dr. Bruno Reichart
Institute for Cardiovascular Physiology and Pathophysiology at the Walter Brendel Center for Experimental Medicine

Original work January 2023: Briukhovetska D, Suarez-Gosalvez J, Voigt C, Markota A, Giannou AD, Schübel M, Jobst J, Zhang T, Dörr J, Märkl F, Majed L, Müller PJ, … , Endres S, Kobold S

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis
journal: Immunity.2023 (JIF 43.47)
first author: Dr. Daria Briukhovetska
Department of Clinical Pharmacology
last author: Prof. Dr. Sebastian Kobold
Department of Clinical Pharmacology

Review January 2023: Anders HJ, Kitching AR, Leung N, Romagnani P

Glomerulonephritis: immunopathogenesis and immunotherapy
journal: Nat Rev Immunol. 2023 (JIF 108.55)
first author: Prof. Dr. Hans-Joachim Anders
Medical Clinic and Polyclinic IV

Original work December 2022: Hermine O, Jiang L, Walewski J, Bosly A, Thieblemont, Szymczyk M, Pott C, Salles G, Feugier P, Hübel K, Haioun C, Casasnovas RO, … , Hoster E, Dreyling M

High-Dose Cytarabine and Autologous Stem-Cell Transplantation in Mantle Cell Lymphoma: Long-Term Follow-Up of the Randomized Mantle Cell Lymphoma Younger Trial of the European Mantle Cell Lymphoma Network
journal: J Clin Oncol. 2022 (JIF 50.74)
last author: Prof. Dr. Martin Dreyling
Medical Clinic and Polyclinic III

Review December 2022: Tiedt S, Buchan AM, Dichgans M, Lizasoain I, Moro MA, Lo EH

The neurovascular unit and systemic biology in stroke - implications for translation and treatment
journal: Nat Rev Neurol. 2022 (JIF 44.71)
first author: Dr. Steffen Tiedt
Institute for Stroke and Dementia Research (ISD)

Original work November 2022: Zambusi A, Novoselc K T, Hutten S, Kalpazidou S, Koupourtidou C, Schieweck R, Aschenbroich S, Silva L, Yazgili A S, van Bebber F, Schmid B, Möller G, Tritscher C, Stigloher C, Delbridge C, Sirko S, Günes Z I, Liebscher S, Schlegel J, Aliee H, Theis F, Meiners S, Kiebler M, Dormann D #, Ninkovic J #

# Contributed equally.

TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury
journal: Nat Neurosci. 2022 (JIF 28.77)
first author: Alessandro Zambusi
Chair of Physiological Genomics, Biomedical Center (BMC)
first author: Klara Tereza Novoselc
Chair of Cell Biology, Biomedical Center (BMC)
last author: Dr. Dorothee Dormann
Chair of Cell Biology, Biomedical Center (BMC) until 2022
last author: Prof. Dr. Jovica Ninkovic
Chair of Cell Biology, Biomedical Center (BMC)

Review November 2022: Märkl F, Huynh D, Endres S, Kobold S

Using chemokines in cancer immunotherapy
journal: Blood. 2023 (JIF 20.3)
first author: Florian Märkl
Department of Clinical Pharmacology
last author: Prof. Dr. Sebastian Kobold
Department of Clinical Pharmacology

Original work October 2022: Hölting T L B, Cidre-Aranaz F, Matzek D, Popper B, Jacobi S J, Funk C M, Geyer F H, Li J, …, Klauschen F, Grünewald T G P #, Knott M M L #

# Contributed equally

Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma
journal: Mol Cancer. 2022 (JIF 41.44)
last author: Dr. Maximilian M. L. Knott Department
of Pathology

Review October 2022: Koutsouleris N, Hauser T, Skvortsova V, De Choudhury M

From promise to practice: towards the realization of AI-informed mental health care
journal: Lancet Digit Health. 2022 (JIF 36.62)
first author: Prof. Dr. Nikolaos Koutsouleris
Clinic and Polyclinic for Psychiatry and Psychotherapy,

Original work September 2022: Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner D C, Kamanu F K, Koido M, …, Ruff C T, Owolabi M O, Huffman J E, Milani L, Kamatani Y, Dichgans M # # , Debette S # #

# Contributed equally.
# # corresponding author.

Stroke genetics informs drug discovery and risk prediction across ancestries
journal: Nature. 2022 (JIF 69.50)
first author: Dr. Rainer Malik
Institute for Stroke and Dementia Research (ISD)
last author: Prof. Dr. Martin Dichgans
Institute for Stroke and Dementia Research (ISD)

Review September 2022: Santovito D, Weber C

Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease
journal: Nat Rev Cardiol. 2022 (JIF 49.42)
first author: Prof. Christian Weber, MD
Institute for Prevention and Epidemiology of Cardiovascular Diseases
last author: Prof. Dr. Donato Santovito
Institute for Prevention and Epidemiology of Cardiovascular Diseases

Original work September 2023: Rizas K D # , Freyer L # , Sappler N #, von Stülpnagel L, Spielbichler P, Krasniqi A , Schreinlechner M, Wenner F N , ... , Massberg S , Bauer A

# Contributed equally.

Smartphone-based screening for atrial fibrillation: a pragmatic randomized clinical trial
journal: Nat Med. 2022 (JIF 87.24)
first author: Dr. Konstantinos Riza's
Medical Clinic and Polyclinic I
first author: Dr. Luisa Freyer
Medical Clinic and Polyclinic I
last author: Prof. Dr. Axel Bauer
Medical Clinic and Polyclinic I

Review August 2022: Ortega G C, Götz M

Centrosome heterogeneity in stem cells regulates cell diversity
journal: Trends Cell Biol. 2022 (JIF 21.17)
last author: Prof. Dr. Magdalena Götz
Chair of Physiological Genomics, Biomedical Center (BMC)

Originalarbeit Juli 2022: Ito-Kureha T, Leoni C , Borland K, Cantini G, Bataclan M, Metzger R, Ammann G, Krug A, Marsico A, Kaiser S, Canzar S, Feske S, Monticelli S, König J, Heissmeyer V

The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells
Journal: Nat Immunol.2022 (JIF 31,25)
Erstautor: Dr. Taku Ito-Kureha
Institut für Immunologie
Letztautor: Prof. Dr. Vigo Heissmeyer
Institut für Immunologie

Review July 2022: Braun C, Carbonell Adames A, Saur D, Rad R

Tutorial: design and execution of CRISPR in vivo screens
journal: Nat Protoc. 2022 (JIF 17.02)
first author: Dr. Christian J. Braun
Pediatric Clinic and Pediatric Outpatient Clinic at Dr. von Hauner Children's Hospital

Original work June 2022: O'Neill A, Uzbas F, Antognolli G, Merino F, Draganova K, Jäck A, Zhang S, Pedini G, ... ,Götz M

Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity
journal: Science.2022 (JIF 63.8)
first author: Dr. Adam C O'Neill
Chair of Metabolic Biochemistry, Biomedical Center (BMC)
last author: Prof. Dr. Magdalena Götz
Chair of Physiological Genomics, Biomedical Center (BMC)

Review June 2022: Ebner B, Volz Y, Mumm J, Stief C, Magistro G

The COVID-19 pandemic—what have urologists learned?
journal: Nat Rev Urol. 2022 (JIF 16.4)
first author: Dr. Benedikt Ebner
Urology Clinic and Polyclinic
last author: Dr. Giuseppe Magistro
Urology Clinic and Polyclinic

Original work May 2022: Chou J, Kaller M, Jaeckel S, Rokavec M, Hermeking H

AP4 suppresses DNA damage, chromosomal instability, and senescence by inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p.
journal: Mol Cancer.2022 (JIF 41.4)
first author: Jinjiang Chou, M.Sc.
Pathology Institute
last author: Prof. Dr. Heiko Hermeking Department
of Pathology

Review May 2022: Georgakis M, Bernhagen J, Heitman L, Weber C, Dichgans M

Targeting the CCL2–CCR2 axis for atheroprotection
journal: Eur Heart J. 2022 (JIF 35.9)
first author: Dr. Marios Georgakis
Institute for Stroke and Dementia Research (ISD)
last author: Prof. Dr. Martin Dichgans
Institute for Stroke and Dementia Research (ISD)

Original work April 2022: Mohanta SK #, Peng L #, Li Y, Lu S, Sun T, Carnevale L, Perrotta M, Ma Z, Förstera B, ..., Weber C #, Lembo G #, Carnevale D#, Habenicht AJR ##

: Contributed equally

Neuroimmune cardiovascular interfaces control atherosclerosis
journal: Nature.2022 (JIF 50.0)
first author: Dr. Sarajo Mohanta
Institute for Prevention and Epidemiology of Cardiovascular Diseases
last author: Prof. Dr. Christian Weber
Institute for Prevention and Epidemiology of Cardiovascular Diseases
last author: Prof. Dr. Andreas Habenicht
Institute for Prevention and Epidemiology of Cardiovascular Diseases

Review April 2022: Lüsebrink E, Kellnar A, Krieg K, Binzenhöfer L, Scherer C, Zimmer S, Schrage B, Fichtner S, Petzold T, ..., Schäfer A #, Orban M##

: Contributed equally

Percutaneous transvalvular microaxial flow pump support in cardiology
journal: Circulation. 2022 (JIF 29.7)
first author: Dr. Dr. Enzo Lüsebrink
Medical Clinic and Polyclinic I
last author: Prof. Dr. Martin Orban
Medical Clinic and Polyclinic I

Original work March 2022: Boas R, Sappler N, von Stülpnagel L, Klemm M, Dixen U, Thune JJ, Pehrson S, Køber L, Nielsen JC, ... , Bauer A # , Rizas KD ##

: Contributed equally

Periodic repolarization dynamics identifies ICD responders in nonischemic cardiomyopathy: A DANISH substudy
journal: Circulation. 2022 (JIF 29.7)
last author: PD Dr. Konstantinos Rizas
Medical Clinic and Polyclinic I

Review March 2022: Mayerle J

Pancreatic cancer: why the cell of origin matters
journal: Nat Rev Gastroenterol Hepatol. 2022 (JIF 46.8)
author: Prof. Dr. Julia Mayerle
Medical Clinic and Polyclinic II

Original work February 2022: Ingelfinger F#, Gerdes LA#, Kavaka V, Krishnarajah S, Friebel E, Galli E, Zwicky P, Furrer R, Peukert C, Dutertre C, ..., Beltrán E* and Becher

B*#: Contributed equally*
: Jointly supervised this work

Twin study reveals non-heritable immune perturbations in multiple sclerosis
journal: Nature. 2022 (JIF 50.0)
first author: PD Dr. Lisa Ann Gerdes
Institute for Clinical Neuroimmunology
last author: Dr. Eduardo Beltrán
Institute for Clinical Neuroimmunology

Review February 2022: Sporns PB, Fullerton HJ, Lee S, Kim H, Lo WD, Mackay MT, Wildgruber M

Childhood stroke
journal: Nat Rev Dis Primers. 2022 (JIF 52.3)
last author: Prof. Dr. Moritz Wildgruber
Department of Radiology

Original work January 2022: Wratil PR, Stern M, Priller A, Willmann A, Almanzar G, Vogel E, Feuerherd M, Cheng C, Yazici S, ..., Keppler OT, Protzer U

Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern
journal: Nat Med. 2022 (JIF 53.4)
first author: Dr. Paul Wratil
Max von Pettenkofer Institute
Chair of Virology
last author: Prof. Dr. Oliver T. Keppler
Max von Pettenkofer Institute
Chair of Virology

Review January 2022: Steffens S, Nahrendorf M, Madonna R

Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies
journal: Eur Heart J. 2021 (JIF 30.0)
first author: Prof. Dr. Sabine Steffens
Institute for Prevention and Epidemiology of Cardiovascular Diseases

Original work December 2021: Krop IE, Im S, Barrios C, Bonnefoi H, Gralow J, Toi M, Ellis PA, Gianni L, ... , Harbeck N

Trastuzumab emtansine plus pertuzumab versus taxanes plus trastuzumab plus pertuzumab after anthracycline for high-risk human epidermal growth factor receptor 2-positive early breast cancer: The phase III KAITLIN study
journal: J Clin Oncol. 2021 (JIF 44.5)
last author: Prof. Dr. Nadia Harbeck
Clinic and Polyclinic for Gynecology and Obstetrics

Review December 2021: Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA

Diagnosis and treatment of primary aldosteronism
journal: Lancet Diabetes Endocrinol. 2021 (JIF 32.1)
first author: Prof. Dr. Martin Reincke
Medical Clinic and Polyclinic IV

Original work November 2021: Kebede Gudina E, Ali S, Girma E, Gize A, Tegene B, Bedada Hundie G, Tsegaye Sime W, Ambachew R, Gebreyohanns A, ..., Andreas Wieser, Arne Kroidl

Seroepidemiology and model-based prediction of SARS-CoV-2 in Ethiopia: longitudinal cohort study among front-line hospital workers and communities
journal: Lancet Global Health. 2021. (JIF 25.7)
last author: Dr. Arne Kroidl
Medical Clinic and Polyclinic IV

Review November 2021: Cardoso F, Cella D, Velikova G, Harmer V, Schumacher-Wulf E, Rihani J, Casas A, Harbeck N

Quality-of-life methodology in hormone receptor-positive advanced breast cancer: Current tools and perspectives for the future
journal: Cancer Treat Rev. 2021 (JIF 12.1)
last author: Prof. Dr. Nadia Harbeck
Clinic and Polyclinic for Gynecology and Obstetrics

Original work October 2021: Weber S, Hellmuth JC, Scherer C, Muenchhoff M, Mayerle J, Gerbes AL

Liver function test abnormalities at hospital admission are associated with severe course of SARS-CoV-2 infection: a prospective cohort study
journal: Good. 2021. (JIF 23.1)
first author: Dr. Sabine Weber
Medical Clinic and Polyclinic II
last author: Prof. Dr. Alexander L. Gerbes
Medical Clinic and Polyclinic II

Review October 2021: Shimabukuro-Vornhagen A, Böll B, Schellongowski P, Valade S, Metaxa V, Azoulay E, von Bergwelt-Baildon M

Critical care management of chimeric antigen receptor T-cell therapy recipients
journal: CA Cancer J Clin. 2021
last author: Prof. Dr. Dr. Michael von Bergwelt
Medical Clinic and Polyclinic III

Original work September 2021: Mahajan UM, Li Q, Alnatsha A, Maas J, Orth M, Maier SH, Peterhansl J, Regel I, Sendler M, ..., Lerch MM, Mayerle J

Tumor-specific delivery of 5-fluorouracil-incorporated epidermal growth factor receptor-targeted aptamers as an efficient treatment in pancreatic ductal adenocarcinoma models
journal: Gastroenterology. 2021. (JIF 22.7)
first author: Ujjwal Mukund Mahajan, PhD
Medical Clinic and Polyclinic II
last author: Prof. Dr. Julia Mayerle
Medical Clinic and Polyclinic II

Review September 2021: Wildner G

Tumors, tumor therapies, autoimmunity, and the eye
journal: Autoimmun Rev. 2021. (JIF 9.8)
author: Prof. Dr. Gerhild Wildner
Eye Clinic

Original work August 2021: Schrodi S, Braun M, Andrulat A, Harbeck N, Mahner S, Kiechle M, Klein E, Schnelzer A, Schindlbeck C, …, Engel J

Outcome of breast cancer patients with low hormone receptor positivity: Analysis of a 15-year population-based cohort
journal: Ann Oncol. 2021. (JIF 33.0)
first author: Dr. Simone Schrodi
Institute for Medical Information Processing, Biometrics, and Epidemiology (IBE)
last author: Prof. Dr. Jutta Engel
Institute for Medical Information Processing, Biometrics, and Epidemiology (IBE)

Review August 2021: Karschnia P, Teske N, Thon N, Subklewe M, Tonn JC, Dietrich J, von Baumgarten L

Chimeric antigen receptor T cells for glioblastoma: Current concepts, challenges, and future perspectives
journal: Neurology. 2021. (JIF 9.9)
first author: Dr. Philipp Karschnia
Neurosurgery Clinic and Polyclinic
first author: Dr. Nico Teske
Neurosurgery Clinic and Polyclinic
last author: PD Dr. Louisa von Baumgarten
Neurosurgery Clinic and Polyclinic

Original work July 2021: Schober A, Blay RM, Saboor Maleki S, Zahedi F, Winklmaier AE, Kakar MY, Baatsch IM, Zhu M, Geißler C, …, Nazari-Jahantigh M

MicroRNA-21 controls circadian regulation of apoptosis in atherosclerotic lesions
journal: Circulation. 2021. (JIF 29.7)
first author: Prof. Dr. Andreas Schober
Institute for Prevention and Epidemiology of Cardiovascular Diseases
last author: Dr. Maliheh Nazari-Jahantigh
Institute for Prevention and Epidemiology of Cardiovascular Diseases

Review July 2021: Kellum JA, Romagnani P, Ashuntantang G, Ronco C, Zarbock A, Anders HJ

Acute kidney injury
journal: Nat Rev Dis Primers. 2021. (JIF 52.3)
last author: Prof. Dr. Hans-Joachim Anders
Medical Clinic and Polyclinic IV

Original work June 2021: Rejeski K, Perez AP, Sesques P, Hoster E, Berger CS, Jentzsch L, Mougiakakos D, Frölich L, Ackermann J, ..., Subklewe M

CAR-HEMATOTOX: A model for CAR T-cell related hematological toxicity in relapsed/refractory large B-cell lymphoma
journal: Blood. 2021. (JIF 22.1)
first author: Dr. Kai Rejeski
Medical Clinic and Polyclinic III
last author: Prof. Dr. Marion Subklewe
Medical Clinic and Polyclinic III

Review June 2021: Briukhovetska, Dörr J, Endres S, Libby P, Dinarello CA, Kobold S

Interleukins in cancer: from biology to therapy
journal: Nat Rev Cancer. 2021. (JIF 60.7)
first author: Dr. Daria Briukhvetska
Department of Clinical Pharmacology
last author: Prof. Dr. Sebastian Kobold
Department of Clinical Pharmacology

Original work May 2021: Gruber T, Pan C, Contreras RE, Wiedemann T, Morgan DA, Skowronski AA, Lefort S, De Bernardis Murat C, Le Thuc O, […] García-Cáceres C

Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension
journal: Cell Metab. 2021. (JIF 27.3)
last author: Prof. Dr. Cristina García-Cáceres
Medical Clinic and Polyclinic IV

Review May 2021: Stark K, Massberg S

Interplay between inflammation and thrombosis in cardiovascular pathology
journal: Nat Rev Cardiol. 2021. (JIF 32.4)
first author: PD Dr. Konstantin Stark
Medical Clinic and Polyclinic I
last author: Prof. Dr. Steffen Massberg
Medical Clinic and Polyclinic I

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