Our research at a glance

One main focus of our department is exploring the cellular and molecular plasticity of neurons, in particular the changes at individual synapses during learning (Kiebler Lab). Synapses undergo dynamic alterations throughout an individual's life, playing a crucial role in learning and memory formation. A key aspect of this process is the localization of specific RNA molecules to the postsynaptic side of synapses, followed by activity-dependent local protein synthesis, which is regulated by RNA-binding proteins (RBPs). These mechanisms contribute significantly to synaptic plasticity.

In the Harner Lab we analyse the different functions of mitochondria that are important for the different cells of the central nervous system (CNS). Since mitochondrial function is intimately linked to their architecture, we are interested in the role of the structural elements of mitochondria in neurons; in particular, we want to understand how mitochondria contribute to neuronal maturation and why altered mitochondrial architecture leads to neurodegeneration.

IIn a parallel approach, we are investigating how newly formed neurons in adulthood ("adult neurogenesis") are integrated into the network of the Hippocampus and how age-related diseases influence the function of the hippocampal network (Pilz Lab). The aim of these studies is to better understand the mechanisms of neuronal adaptation and degeneration.

The Ninkovic Lab is developing strategies for the repair and regeneration of the brain. In particular, we are investigating how the glial cells can be functionally modified to promote the regeneration of neurons.

In addition to neurons, we also investigate fundamental mechanisms of human reproduction and its disorders. We use ovarian and testicular cells as model systems of the gonads in order to understand the differentiation and function of these cells and corresponding tumor cells (Mayerhofer Lab).

In the Müller-Taubenberger Lab, we investigate the dynamics of the actin cytoskeleton in non-muscle cells, which plays a central role in cell structure. Our aim is to elucidate the molecular basis of actin-based processes that are essential for cell motility, subcellular organization and the structural integrity of the cell.

We use state-of-the-art experimental cell biological approaches, from the culture of primary neurons including live cell imaging, spheroids and organoids to mouse models including genetics and molecular methods (hiCLIP, Mass Spec, proximity ligation assays) to comprehensively investigate complex cellular processes.