Klein Lab

Thymus Function

Landscape portrait of Ludger Klein.

© J. Greune / LMU

Prof. Dr. Ludger Klein

Thymus Function
Institute of Immunology

+49 89 2180 75427
ludger.klein@med.lmu.de

Research Topics

  • T cell repertoire selection
  • Central T cell tolerance
  • Regulatory T cells

We aim to elucidate the cellular interactions and molecular pathways that orchestrate the generation of a 'useful' T cell repertoire and imprint self-tolerance. To do so, we employ genetically manipulated mouse models that allow us to dissect T-cell-intrinsic and -extrinsic determinants shaping the T cell pool during repertoire selection in the thymus. Read more...

Scientific vita

since 2007
Associate professor, Institute for Immunology, Biomedical Center, LMU Munich
2001-2007
Group leader, Research Institute of Molecular Pathology (IMP), Vienna, Austria
1999-2001
Postdoctoral researcher, von Boehmer Lab, Dana-Farber-Cancer Institute, Boston, USA
1997-1999
Postdoctoral researcher, Kyewski Lab, German Cancer Research Institute (DKFZ), Heidelberg
1993-1997
PhD in Biology, University of Cologne / DKFZ Heidelberg, Advisors: Howard and Kyewski