T Cell Activation – AG Reinhard Obst

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PD Dr. Reinhard Obst
Institute for Immunology
Biomedical Center
LMU Munich
Großhadernerstr. 9
82152 Planegg-Martinsried

Germany

+49 (0)89 2180 75631
reinhard.obst@med.uni-muenchen.de

Research Focus

• T Cell Activation
  
• Gene Expression
  
• T Cell Receptor Signaling
  
• Acute and Chronic Infections

Selected Publications

OrcID: https://orcid.org/0000-0002-4839-207X

Rosenlehner, T., Pennavaria, S., Akcabozan, B., Jahani, S., O'Neill, T. J., Krappmann, D., Straub, T., Kranich, J. and Obst, R. (2024 Oct 22) Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells. Sci Signal 2024. 17: eadi8753. DOI: 10.1126/scisignal.adi8753 (link)

Trefzer, A., Kadam, P., Wang, S. H., Pennavaria, S., Lober, B., Akçabozan, B., Kranich, J., Brocker, T., Nakano, N., Irmler, M., Beckers, J., Straub, T. and Obst, R., Dynamic adoption of anergy by antigen-exhausted CD4+ T cells. Cell Rep 2021. 34: 108748. DOI: 10.1016/j.celrep.2021.108748

Obst, R. (2015). The timing of T cell priming and cycling. Front Immunol 6, 563.

Rabenstein, H., Behrendt, A.C., Ellwart, J.W., Naumann, R., Horsch, M., Beckers, J., and Obst, R. (2014). Differential kinetics of antigen dependency of CD4+ and CD8+ T cells. J Immunol 192, 3507-3517.

Hoerr, I., Obst, R., Rammensee, H.G., and Jung, G. (2000). In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies. Eur J Immunol 30, 1-7.

Team Members AG Obst