News
Unexpected Roles of Neural Stem Cell Proteins
17 Jun 2026
Magdalena Götz and her team mapped the nuclear and cytoplasmic proteomes of neural stem cells and discovered that many cytoskeletal proteins are present in the nucleus.
© Jan Greune
Her team identified MAP1B as a key regulator that shuttles between the cytoplasm and nucleus, where it interacts with the BAF chromatin-remodeling complex. Disease-associated MAP1B mutations increase its nuclear localization, alter chromatin regulation, and disrupt brain development.
Read more on the SyNergy website (News | 12/06/2026 | Research Spotlight).