Murawska Lab

Vergrößern

Dr. Magdalena Murawska

Histone chaperones in health and disease
Division of Physiological Chemistry

+49 89 2180 71152

magdalena.murawska@bmc.med.lmu.de

Research Topics

• Chromatin structure
• Chromatin dynamics during cell cycle
• Histone chaperones

DNA within our cells is tightly packed into nucleosomes, formed by small yet crucial proteins called histones. Histones don’t act alone but they are assisted by specialized proteins known as histone chaperones, which assemble or disassemble histones into nucleosomes. This dynamic process is key for maintaining genome stability and keeping DNA accessible when needed. Alterations in histones and histone chaperone expression are linked to various cancer types, where they likely play a critical role in the survival of highly proliferative cancer cells. Our lab is focused on studying histone chaperone complexes, highly conserved from yeast to humans, to understand how they impact chromatin dynamics across the cell cycle and their potential impact on cancer survival. Read more

Publications

https://orcid.org/0000-0001-8956-7545