Kranich Lab
Extracellular vesicles and B cell immunity
© privat
Dr. Jan Kranich
Extracellular Vesicles and B cell Immunity
Institute for Immunology
Research Topics
- Targeting of extracellular vesicles
- Vaccine Design
- B cell responses
- Bioengineering
Our research explores how naturally occurring endogenous extracellular vesicles (EVs) can be leveraged to improve immune responses. Fusion of antigen with PS-binding proteins allows us to target antigens specifically to endogenous extracellular vesicles, creating a novel mode of antigen delivery. Such EV-targeted antigen (EVtAg) enables rapid and immune complex-independent delivery of antigen to follicular dendritic cells, accelerating activation of B cells and enhancing the quality of the adaptive immune response. Our findings uncover a new physiological pathway for B cell activation, which we are currently exploiting to create more effective vaccines.
Publications
- Since 2025
- Group leader, Institute for Immunology, Biomedical Center, LMU Munich
- Since 2024
- Lecturer, Institute for Immunology, Biomedical Center, LMU Munich
- 2012-2024
- Scientist, Institute for Immunology, Biomedical Center, LMU Munich
- 2009-2011
- Postdoc, Garvan Institute for Medical Research, Sydney, Australia
- 2008-2009
- Postdoc, University Hospital Zurich, Switzerland
- 2008
- PhD in Biology, University Hospital Zurich, Switzerland. Advisor: Adriano Aguzzi