Basilicata Lab
Molecular gene regulation
Dr. M. Felicia Basilicata | © privat
Dr. M. Felicia Basilicata
Molecular gene regulation
Division of Physiological Chemistry
- This new professorship and lab group starts in September 2025 -
Research Topics
- Convergent pathways in neuronal vulnerability
- Non-canonical chromatin factor functions
- Sex-biased disease mechanisms
Our laboratory investigates the molecular mechanisms underlying rare neurodevelopmental disorders (NDDs) using a variety of methods including CRISPR engineering, high-resolution microscopy, multi-omics approaches, and both 2D and 3D embryonic stem cell cultures in human and mouse models. We study how genetic alterations affecting chromatin machinery disrupt cellular homeostasis and how diverse mutations converge on similar developmental bottlenecks. Our research addresses the pronounced sex bias in NDDs by examining X-chromosome inactivation escape mechanisms and tissue-specific regulation. Through these investigations, we aim to develop personalized therapeutic approaches targeting common downstream effects rather than individual causative mutations. Read more...
Publications
- Sep 2025
- Associate Professor for Molecular Gene Regulation, Department of Physiological Chemistry, Biomedical Center, LMU Munich
- 2022-2025
- Group Leader, Institute for Human Genetic, University Medical Center (UMC), Mainz (HPG fellowship)
- 2020-2025
- Senior Research Associate, Institute of Molecular Biology, Mainz
- 2020-2021
- Team Lead An Interim (Gene dosage alterations lab, maternity leave), Institute of Molecular Biology, Mainz
- 2014-2020
- Postdoctoral Fellow; MPI of Immunobiology & Epigenetics, Freiburg